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Human growth hormone (hgh) for “dummies” by mark hilton profmark@gmail. Com keywords: growth hormone, human growth hormone (hgh)3, somatotropin5, sermorelin, hgh therapy. Introduction to human growth hormone as one cocky news reporter put it, “unless you’re sleeping under a rock, you’ve probably heard about human growth hormone”. Human growth hormone (gh) is a substance that controls your body’s growth. Gh is made by the pituitary gland, located at the base of the brain. Gh helps children grow taller (also called linear growth), increases muscle mass, and decreases body fat. Regulation of human growth hormone secretion and its disorders growth hormone (gh) secretion from anterior pituitary is regulated by the hypothalamus and the mediators of gh actions. Major regulatory factors include gh releasing hormone (ghrh), somatostatin (srif), gh releasing peptide (ghrerin) and insulin-like growth factor (igf-i). Secretion of growth hormone (gh) in the pituitary is regulated by the neurosecretorynuclei of the hypothalamus. These cells release the peptides growth hormone-releasing hormone(ghrh or somatocrinin) and growth hormone-inhibiting hormone(ghih or somatostatin) into the hypophyseal portalvenous blood surrounding the pituitary. Hormone production and serum hormone concentrations are maintained by feedback mechanisms. Target glands, such as the thyroid gland, adrenal glands, and gonads, are under distant feedback regulation by the hypothalamic-pituitary-target gland axis. Other hormonal systems, however, are under direct feedback regulation mechanisms. Human growth hormone (hgh) is a substance secreted by the pituitary gland that promotes growth during childhood and adolescence. Growth hormone fuels childhood growth and helps maintain tissues and organs throughout life. It's produced by the pea-sized pituitary gland — located at the base of the brain. Beginning in middle age, however, the pituitary gland slowly reduces the amount of growth hormone it produces. This gene encodes a protein that is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to reorientation of a pre-assembled receptor dimer dimerization (the receptor may however also exist as monomers on the cell surface ) and the activation of an intra- and intercellular signal transduction pathway leading to growth. The most well-known regulator is growth hormone releasing hormone ghrh. It is a 44 amino acid peptide hormone produced in the hypothalamus. The primary function of ghrh is to stimulate the release of human growth hormone in the body. The secretion of growth hormone (gh) is controlled by a complex regulatory system. The primary control is exerted by two neuroendocrine hormones, gh-releasing hormone and somatostatin, though other hypothalamic neuropeptides directly and indirectly participate in this process. The pituitary gland stimulates the release of growth hormone and is essential for regulating bone growth, especially during puberty. Growth hormone stimulates the production of igf-1, which is produced in the liver and released in the blood
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